The Blues are currently fourth in the league standings and need to beat the Bees to avoid dropping down the table.
Ahead of the game, Maresca has made multiple changes from the 1-0 win over Tottenham Hotspur on Thursday.
Robert Sanchez continues in goal, but there are changes in the backline.
Reece James captains the side from right-back while Malo Gusto has got the nod to start from the opposite end.
Tosin Adarabioyo will partner Trevoh Chalobah in central defence. Marc Cucurella and Levi Colwill are on the bench.
Moises Caicedo starts as the holding midfielder.
He will be partnered by Kiernan Dewsbury-Hall with Enzo Fernandez operating as the number 10 against the Bees.
Noni Madueke and Jadon Sancho start on the right and left wing with Christopher Nkunku getting the nod upfront.
Cole Palmer, Pedro Neto and Nicolas Jackson have been given a breather. The trio are on the bench as part of rotation.
Confirmed Chelsea line-up (4-2-3-1) vs Brentford: Sanchez; James, Tosin, Chalobah, Gusto; Caicedo, Dewsbury-Hall; Madueke, Fernandez, Sancho; Nkunku.