The Gunners beat the Eagles in the Carabao Cup quarter-final in midweek. They registered an impressive 3-2 comeback win at the Emirates Stadium.
Arsenal now face their London rivals on the road and will be aiming to return to winning ways in the league after back-to-back draws.
Formation: 4-2-3-1
Predicted Line-up:
David Raya is guaranteed to continue in goal for the Gunners this evening. He has been in exceptional form with several top-class saves.
In defence, there could be three changes with Jakub Kiwior, Kieran Tierney and Thomas Partey dropping down to the substitutes' bench.
William Saliba is expected to partner Gabriel Magalhaes in central defence with Jurrien Timber and Riccardo Calafiori in the full-back spots.
Calafiori has returned to full team training after his groin issue and we won't be surprised if he is reinstated straight into the XI today.
In central midfield, Declan Rice should replace Jorginho after his return from injury. He is set to be partnered by Mikel Merino.
Martin Odegaard is a nailed-on starter in the no.10 role when it comes to the Premier League and Champions League games for Arsenal.
He was brilliant in midweek with a couple of assists off the bench. The Norwegian should get the nod over Ethan Nwaneri in the XI.
Gabriel Jesus is expected to lead the line following his maiden club hat-trick, but there could be changes in the wide attacking positions.
Leandro Trossard and Raheem Sterling should make way for Gabriel Martinelli and Bukayo Saka for the left and right wing spots respectively.
Predicted Arsenal line-up (4-2-3-1): Raya; Timber, Saliba, Gabriel, Calafiori; Rice, Merino; Saka, Odegaard, Martinelli; Jesus.