The Red Devils will be aiming to secure back-to-back league wins for the first time this campaign.
Formation: 3-4-2-1
Predicted Line-up:
Andre Onana is an undisputed starter in goal for the Red Devils. He is guaranteed to keep his place between the sticks.
The backline could see two changes. Victor Lindelof was poor against Leicester City and could drop to the substitutes' bench.
The Swede could make way alongside Ayden Heaven, who is on the sidelines after picking up an injury against the Foxes.
Harry Maguire and Leny Yoro recently returned from injuries. The duo are likely to partner Matthijs de Ligt in central defence.
Noussair Mazraoui could get the nod over Diogo Dalot at right wing-back. Patrick Dorgu, who is available after a three-match domestic ban, looks set to start from the left wing-back position tonight.
The midfield should stay unchanged. Manuel Ugarte and Bruno Fernandes have formed a terrific partnership in the centre of the park.
Alejandro Garnacho is likely to be accompanied by Joshua Zirkzee in attacking midfield. Rasmus Hojlund should lead the line.
Predicted Man Utd line-up (3-4-2-1) vs Forest: Onana; De Ligt, Maguire, Yoro; Mazraoui, Ugarte, Fernandes, Dorgu; Zirkzee, Garnacho; Hojlund.