The Red Devils suffered a 3-2 loss to Forest at Old Trafford earlier this campaign. They will be aiming to avenge the defeat on Tuesday.
Ahead of the game, manager Ruben Amorim has confirmed that Harry Maguire and Leny Yoro are fully fit to make the squad.
The duo sustained injuries prior to the international break. They have fully recovered and could be involved against Forest at City Ground.
However, the game will come too soon for Luke Shaw and Kobbie Mainoo. They need a couple of more training sessions to return.
Amad Diallo, Jonny Evans and Ayden Heaven are also on the sidelines at the moment, but they could be fit before the season ends.
Lisandro Martinez remains the only long-term absentee. The Argentine underwent a knee surgery earlier this year and may not return until December.